Production and Supply of α-Particle–Emitting Radionuclides for Targeted α-Therapy
Valery Radchenko, Alfred Morgenstern, Amir Reza Jalilian, Caterina F. Ramogida, Cathy Cutler, Charlotte Duchemin, Cornelia Hoehr, Ferrid Haddad, Frank Bruchertseifer, H. Gausemel, Hua Yang, João Alberto Osso, Kohshin Washiyama, Kenneth R. Czerwinski, Kirsten Leufgen, Marek Pruszyński, Olga Valzdorf, Patrick Causey, Paul Schaffer, Randy Perron, Samsonov Maxim, D. Scott Wilbur, Thierry Storà, Yawen Li
Abstract
Encouraging results from targeted α-therapy have received significant attention from academia and industry. However, the limited availability of suitable radionuclides has hampered widespread translation and application. In the present review, we discuss the most promising candidates for clinical application and the state of the art of their production and supply. In this review, along with 2 forthcoming reviews on chelation and clinical application of α-emitting radionuclides, <i>The Journal of Nuclear Medicine</i> will provide a comprehensive assessment of the field.