Site-Selective Defluorinative sp<sup>3</sup> C–H Alkylation of Secondary Amides
Wen‐Jun Yue, Craig S. Day, Rubén Martı́n
Abstract
A site-selective defluorinative sp3 C–H alkylation of secondary amides that rapidly and reliably incorporates gem-difluoroalkene motifs into previously unfunctionalized sp3 sites is disclosed. This protocol is distinguished by its mild conditions, wide scope, and exquisite site-selectivity, thus unlocking a new platform to introduce carbonyl isosteres at saturated hydrocarbon sites.
Topics & Concepts
ChemistryAlkylationSelectivityHydrocarbonOrganic chemistryCombinatorial chemistryCatalysisCatalytic C–H Functionalization MethodsFluorine in Organic ChemistryAdvanced Synthetic Organic Chemistry