Design, synthesis and biological evaluation of novel estrone phosphonates as high affinity organic anion-transporting polypeptide 2B1 (OATP2B1) inhibitors
Rebeka Jójárt, Réka Laczkó-Rigó, Máté Klement, Gabriella Kőhl, Gábor Kecskeméti, Csilla Özvegy‐Laczka, Erzsébet Mernyák
Topics & Concepts
ChemistryEstroneEstrone sulfateSteroidMoietyLinkerStereochemistryConjugateStructure–activity relationshipTransporterBiochemistryClick chemistryCombinatorial chemistryHormoneIn vitroComputer scienceMathematicsOperating systemGeneMathematical analysisDrug Transport and Resistance MechanismsDNA and Nucleic Acid ChemistryHIV/AIDS drug development and treatment