A Second-Generation Fungerp Analog, SCY-247, Shows Potent <i>In Vitro</i> Activity against Candida auris and Other Clinically Relevant Fungal Isolates
Sherman Chu, Lisa Long, R. Sherif, Thomas S. McCormick, Katyna Borroto–Esoda, Stephen Barat, Mahmoud A. Ghannoum
Abstract
Due to the increase of antifungal drug resistance and difficulties associated with drug administration, new antifungal agents for invasive fungal infections are needed. SCY-247 is a second-generation fungerp antifungal compound that interferes with the synthesis of the fungal cell wall polymer β-(1,3)- d -glucan.
Topics & Concepts
Candida aurisAntifungalMicrobiologyIn vitroAntifungal drugDrug resistanceCandida infectionsDrugBiologyPharmacologyAntifungal drugsBiochemistryAntifungal resistance and susceptibilityFungal Infections and StudiesFungal Biology and Applications