Microfluidic organ-on-a-chip models for the gut–liver axis: from structural mimicry to functional insights
Weifeng Hu, Yushen Wang, Junlei Han, Wenhong Zhang, Jun Chen, Xinyu Li, Li Wang
Abstract
This review discusses advancements in organ-on-a-chip models, emphasizing gut, liver, and integrated gut–liver systems. It covers their applications in disease modeling, toxicity testing, and drug screening, as well as future prospects.
Topics & Concepts
Organ-on-a-chipMimicryMicrofluidic chipLiver toxicityMicrofluidicsMolecular mimicryMechanism (biology)Computational biologyComputer scienceBiologyToxicityNanotechnologyMedicineImmunologyInternal medicineEcologyPhilosophyMaterials scienceEpistemologyAntigen3D Printing in Biomedical ResearchInnovative Microfluidic and Catalytic Techniques InnovationMicrofluidic and Capillary Electrophoresis Applications