Androgen-regulated MafB drives cell migration via MMP11-dependent extracellular matrix remodeling in mice
Mellissa C. Alcantara, Kentaro Suzuki, Alvin R. Acebedo, Daiki Kajioka, Satoshi Hirohata, Tsuneyasu Kaisho, Yu Hatano, Kazuo Yamagata, Satoru Takahashi, Gen Yamada
Abstract
loss-of-function mice. These results demonstrate the requirement of mesenchymal-derived androgen signaling on ECM-dependent cell migration, providing insights into the regulatory cellular mechanisms underlying androgen-driven sexual differentiation.
Topics & Concepts
Cell biologyExtracellular matrixBiologyFibronectinCell migrationIntegrinTranscription factorAndrogenCellEndocrinologyGeneticsGeneHormoneProstate Cancer Treatment and ResearchProtease and Inhibitor MechanismsTGF-β signaling in diseases