Prenylated <i>p</i>-Terphenyls from a Mangrove Endophytic Fungus, <i>Aspergillus candidus</i> LDJ-5
Guoliang Zhou, Xiaohui Chen, Xiaomin Zhang, Qian Che, Guojian Zhang, Tianjiao Zhu, Qianqun Gu, Dehai Li
Abstract
Nine previously undescribed prenylated p-terphenyls, prenylterphenyllins F–J (1, 2, 4–6) and prenylcandidusins D–G (3, 7–9), were isolated from an endophytic fungus, Aspergillus candidus LDJ-5. Their structures were determined from NMR and MS data. Differing from previously reported p-terphenyls, compound 3 represents a rare 6,5,6,6-fused ring system. Compounds 4–6 are antimicrobial, and compounds 1, 4, 6, and 9 are cytotoxic.
Topics & Concepts
MangroveStereochemistryPrenylationFungusAspergillusAntimicrobialTwo-dimensional nuclear magnetic resonance spectroscopyChemistryBotanyBiologyOrganic chemistryEcologyEnzymeMicrobial Natural Products and BiosynthesisEssential Oils and Antimicrobial ActivityPhytochemical compounds biological activities