Methods for Quantifying the Metabolic Boundary Fluxes of Cell Cultures in Large Cohorts by High-Resolution Hydrophilic Liquid Chromatography Mass Spectrometry
Ryan A. Groves, Maryam Mapar, Raied Aburashed, Luis F. Ponce, Stephanie L. Bishop, Thomas Rydzak, Marija Drikic, Dominique Bihan, Hallgrímur Benediktsson, Fiona Clement, Daniel B. Gregson, Ian A. Lewis
Abstract
isolated from bloodstream infections. These data capture the diversity of metabolic phenotypes observed in clinical isolates and provide an example of how large-scale investigations can leverage our novel analytical strategy.
Topics & Concepts
ChemistryMetabolomicsMass spectrometryChromatographyHydrophilic interaction chromatographyLiquid chromatography–mass spectrometryLeverage (statistics)Resolution (logic)Biological systemHigh-performance liquid chromatographyStatisticsMathematicsArtificial intelligenceBiologyComputer scienceMetabolomics and Mass Spectrometry StudiesAnalytical Chemistry and ChromatographyMass Spectrometry Techniques and Applications