Pathophysiology of chronic peripheral ischemia: new perspectives
Salvatore Santo Signorelli, Luca Vanella, Nader G. Abraham, Salvatore Scuto, Elisa Marino, Petra Ročić
Abstract
Peripheral arterial disease (PAD) affects individuals particularly over 65 years old in the more advanced countries. Hemodynamic, inflammatory, and oxidative mechanisms interact in the pathophysiological scenario of this chronic arterial disease. We discuss the hemodynamic, muscle tissue, and oxidative stress (OxS) conditions related to chronic ischemia of the peripheral arteries. This review summarizes the results of evaluating both metabolic and oxidative markers, and also therapy to counteract OxS. In conclusion, we believe different pathways should be highlighted to discover new drugs to treat patients suffering from PAD.
Topics & Concepts
MedicinePathophysiologyPeripheralIschemiaOxidative stressDiseaseHemodynamicsCardiologyArterial diseaseInternal medicineVascular diseasePeripheral Artery Disease ManagementCerebrovascular and Carotid Artery DiseasesVenous Thromboembolism Diagnosis and Management