Vasodilation in patients with calcium channel blocker poisoning treated with high-dose insulin: a comparison of amlodipine versus non-dihydropyridines
Jon B. Cole, Samantha Lee, Matthew E. Prekker, Nathan M. Kunzler, Kelly A. Considine, Brian E. Driver, Michael A. Puskarich, Travis D. Olives
Abstract
Amlodipine poisoned patients treated with HDI required more vasopressors, higher doses of epinephrine, and more often received rescue methylene blue than similarly treated patients with verapamil or diltiazem poisoning. These differences suggest amlodipine-poisoned patients had more evidence of vasodilation. Further study is warranted to determine if synergistic vasodilation occurs when HDI is used to treat amlodipine poisoning.
Topics & Concepts
AmlodipineMedicineVerapamilVasodilationDiltiazemCalcium channel blockerFelodipineDihydropyridinePharmacologyAnesthesiaInternal medicineCalciumBlood pressurePoisoning and overdose treatmentsPharmacology and Obesity TreatmentCardiovascular Syncope and Autonomic Disorders