Tracking the fates of iron-labeled tumor cells <i>in vivo</i> using magnetic particle imaging
Ashley V. Makela, Melissa Schott, Olivia C. Sehl, Julia J. Gevaert, Paula J. Foster, Christopher H. Contag
Abstract
BLI, and correlated these positive contrast images with CT scans to reveal the anatomic sites with cancer cells; histologic analysis confirmed the presence of iron-labeled tumor cells in the tissues, suggesting that the metastatic cells retained enough iron for MPI detection. The use of multi-modality cell tracking reveals the movement, accumulation and fates of labeled cells that will be helpful understanding cancer progression and guiding the development of targeted therapies.
Topics & Concepts
Magnetic resonance imagingIn vivoMetastasisCellPreclinical imagingCancer cellMagnetic particle imagingPathologyCancer researchCancerChemistryMedicineBiologyRadiologyMagnetic nanoparticlesMaterials scienceNanotechnologyNanoparticleBiochemistryInternal medicineBiotechnologyCharacterization and Applications of Magnetic NanoparticlesGeomagnetism and Paleomagnetism StudiesMicrofluidic and Bio-sensing Technologies