Dual inhibitors of ASK1 and PDK1 kinases: Design, synthesis, molecular docking and mechanism studies of N-benzyl pyridine-2-one containing derivatives as anti-fibrotic agents
Jia Qin, Meng Cao, Xinlan Hu, Wenhua Tan, Binghao Ma, Yuanyuan Cao, Zhuo Chen, Qianbin Li, Gaoyun Hu
Topics & Concepts
ChemistryKinaseASK1Docking (animal)p38 mitogen-activated protein kinasesProtein kinase BEnzymeBiochemistryPhosphorylationPyridineStereochemistryProtein kinase ACyclin-dependent kinase 2Medicinal chemistryNursingMedicineRedox biology and oxidative stressSynthesis and biological activityGenomics, phytochemicals, and oxidative stress