The many faces of cGAS: how cGAS activation is controlled in the cytosol, the nucleus, and during mitosis
Anna‐Maria Herzner, Martin Schlee, Eva Bartok
Abstract
Psychosocial stress is one of the main environmental factors contributing to the development of psychiatric disorders. In humans and rodents, chronic stress is associated with elevated inflammatory responses, indicated by increased numbers of circulating myeloid cells and activation of microglia, the brain-resident immune cells. The endocannabinoid system (ECS) regulates neuronal and endocrine stress responses via the cannabinoid receptor 1 (CB1). CB1-deficient mice (Cnr1
Topics & Concepts
MitosisNucleusCytosolCell biologyChemistryCell nucleusBiologyBiochemistryEnzymeUbiquitin and proteasome pathwaysinterferon and immune responsesToxoplasma gondii Research Studies