Optical coherence tomography split-spectrum amplitude-decorrelation optoretinography
Siyu Chen, Shuibin Ni, Alfonso Jiménez Villar, Yifan Jian, Yali Jia, David Huang
Abstract
This pilot study reports the development of optical coherence tomography (OCT) split-spectrum amplitude-decorrelation optoretinography (SSADOR) that measures spatially resolved photoreceptor response to light stimuli. Using spectrally multiplexed narrowband OCT, SSADOR improves sensitivity to microscopic changes without the need for cellular resolution or optical phase detection. Therefore, a large field of view (up to 3 × 1 mm 2 demonstrated) using conventional OCT instrument design can be achieved, paving the way for clinical translation. SSADOR promises a fast, objective, and quantifiable functional biomarker for photoreceptor damage in the macula.
Topics & Concepts
Optical coherence tomographyDecorrelationOpticsNarrowbandPhysicsOptical tomographyAmplitudeTomographySensitivity (control systems)Coherence (philosophical gambling strategy)Computer scienceComputer visionQuantum mechanicsElectronic engineeringEngineeringOptical Coherence Tomography ApplicationsRetinal Diseases and TreatmentsRetinal Imaging and Analysis