3D visualization of trans-syncytial nanopores provides a pathway for paracellular diffusion across the human placental syncytiotrophoblast
Rohan M. Lewis, Harikesan Baskaran, Jools Green, Stanimir Asenov Tashev, Eleni Palaiologou, Emma M. Lofthouse, Jane K. Cleal, Anton Page, David S. Chatelet, Patricia Goggin, Bram G. Sengers
Abstract
of placental tissue could explain experimentally observed placental paracellular diffusion. TSNs may mediate physiological hydrostatic and osmotic pressure homeostasis between the maternal and fetal circulations but also expose the fetus to pharmaceuticals, environmental pollutants, and nanoparticles.
Topics & Concepts
SyncytiotrophoblastParacellular transportCell biologyFetusTransplacentalBiophysicsChemistryAdherens junctionSyncytiumTranscellularPlacentaBiologyCellPermeability (electromagnetism)BiochemistryMembranePregnancyGeneticsCadherinPregnancy and preeclampsia studiesNeonatal Respiratory Health ResearchExtracellular vesicles in disease