Analyses of the autism-associated neuroligin-3 R451C mutation in human neurons reveal a gain-of-function synaptic mechanism
Le Wang, Vincent R. Mirabella, Rujia Dai, Xiao Su, Ranjie Xu, Azadeh Jadali, Matteo Bernabucci, Ishnoor Singh, Yu Chen, Jianghua Tian, Peng Jiang, Kelvin Y. Kwan, ChangHui Pak, Chunyu Liu, Davide Comoletti, Ronald P. Hart, Chao Chen, Thomas C. Südhof, Zhiping P. Pang
Topics & Concepts
NeuroliginExcitatory postsynaptic potentialNeurotransmissionBiologyMutationInhibitory postsynaptic potentialForebrainNeurosciencePostsynaptic potentialExcitatory synapseSynapseCell biologyGeneGeneticsCentral nervous systemReceptorAutism Spectrum Disorder ResearchSingle-cell and spatial transcriptomicsCRISPR and Genetic Engineering