In vivo characterization of 3D-printed polycaprolactone-hydroxyapatite scaffolds with Voronoi design to advance the concept of scaffold-guided bone regeneration
Markus Laubach, Buddhi Herath, Nathalie Bock, Sinduja Suresh, Siamak Saifzadeh, Bronwin Dargaville, Jacqui McGovern, Marie‐Luise Wille, Dietmar W. Hutmacher, Flávia Medeiros Savi
Abstract
degradation (mass loss <1%) was observed over the period of 6 months. After loading the scaffolds with different types of fresh sheep xenograft and ectopic implantation in rats for 8 weeks, highly vascularized tissue without extensive fibrous encapsulation was found in all mPCL-HA Voronoi scaffolds and endochondral bone formation was observed, with no adverse host-tissue reactions. This study supports the use of mPCL-HA Voronoi scaffolds for further testing in future large preclinical animal studies prior to clinical trials to ultimately successfully advance the SGBR concept.