Development of the Deoxycorticosterone Acetate (DOCA)-salt Hypertensive Rat Model
Nayara Pestana‐Oliveira, David Nahey, Tim Johnson, John P. Collister
Abstract
, the DOCA-salt model. This model is known to have a neurogenic component linked to increased sympathetic nervous system activity, and as such the DOCA-salt model promotes cross-talk between endocrine and neural components that lead to increased blood pressure, and may impact the functioning of other organs.
Topics & Concepts
Blood pressureEndocrine systemMedicineGenetic modelDiseaseAnimal modelEndocrinologySympathetic nervous systemPathogenesisInternal medicineBioinformaticsBiologyHormoneGeneBiochemistryHormonal Regulation and HypertensionStress Responses and CortisolRenin-Angiotensin System Studies