Synthesis of novel 5-(2,5-bis(2,2,2-trifluoroethoxy)phenyl)-1,3,4-oxadiazole-2-thiol derivatives as potential glucosidase inhibitors
Ramesh S. Gani, Avinash K. Kudva, Karabasanagouda Timanagouda, Raghuveer, Salma Begum Hussain Mujawar, Shrinivas D. Joshi, Shamprasad Varija Raghu
Topics & Concepts
AcarboseChemistryOxadiazoleIn vivoIC50Docking (animal)Lead compoundActive siteStereochemistryThiolProtein Data Bank (RCSB PDB)EnzymeHydantoinIn vitroBiochemistryOrganic chemistryBiotechnologyBiologyNursingMedicineNatural Antidiabetic Agents StudiesEnzyme Production and CharacterizationEnzyme function and inhibition