GPR43 regulates sodium butyrate-induced angiogenesis and matrix remodeling
Pollyana Ribeiro Castro, Lucas Felipe Fernandes Bittencourt, Sébastien Larochelle, Sílvia Passos Andrade, Charles R. Mackay, Mark Slevin, Véronique Moulin, Lucíola S. Barcelos
Abstract
Our data show the contribution of the metabolite-sensing receptor GPR43 in the effects of low dose of sodium butyrate (NaBu) on stimulating angiogenesis and extracellular matrix remodeling in a model of granulation tissue formation in mice. We also show that human dermal fibroblasts, myofibroblasts, and endothelial cells express the receptor GPR43. These data provide important insights for the use of NaBu in local therapeutic approaches applicable to tissue repair in sites other than the intestine.
Topics & Concepts
AngiogenesisSodium butyrateChemistryMatrix (chemical analysis)Cell biologyBiologyCancer researchBiochemistryGeneChromatographySignaling Pathways in DiseasePeptidase Inhibition and AnalysisDiabetes Treatment and Management