Polyurethane‐Based Bioglue for the Repair of Arterial Ruptures
Wenxuan Wu, Chengkai Xuan, Yaqiang Jiang, Haotian Lu, Shengtao Yan, Xuetao Shi
Abstract
Abstract A bioglue with fast blood absorption and strong adhesion, capable of stopping bleeding through physical blockage rather than coagulation, is imperative for treating arterial hematorrhea during surgery and in wilderness first aid. Here, we developed a two‐component polyurethane‐based arterial glue (PAG). The key strategy of this work is to optimize the hydrophilicity and crosslinking density of the bioglue by modulating the proportion of hydrophilic polyethylene glycol (PEG)‐based urethane prepolymer, the hydrophobicamine crosslinkers, and the functionality of the crosslinkers. Compared with commercial PEG‐based bioglue, PAG has a similar water absorption rate but less swelling. Furthermore, owing to the hydrogen bonding originating from the urethane/urea bonds and extracovalent bond formation with tissue, PAG showed ≈2 times greater adhesive strength than commercial PEG‐based bioglues. In addition, PAG has good hemocompatibility and maintains cured integrity even under circulating blood flushing conditions, thereby reducing the risk of arterial embolism. This bioglue demonstrated a more reliable sealing effect with a higher survival rate compared to commercial fibrin and PEG‐based bioglues on the rat abdominal aorta and rabbit carotid artery in open operations; moreover, it can be assembled into a commercial balloon dilation catheter system, enabling minimally invasive surgeries on the porcine femoral artery.