Radiosynthesis and evaluation of a fluorine-18 radiotracer [<sup>18</sup>F]FS1P1 for imaging sphingosine-1-phosphate receptor 1
Lin Qiu, Hao Jiang, Yanbo Yu, Jiwei Gu, Jinzhi Wang, Haiyang Zhao, Tianyu Huang, Robert J. Gropler, Robyn S. Klein, Joel S. Perlmutter, Zhude Tu
Abstract
A promising sphingosine-1-phosphate receptor 1 PET radiotracer [ 18 F]FS1P1 was synthesized using a facile multiple step F-18 radiochemistry procedure.
Topics & Concepts
RadiosynthesisSphingosine-1-phosphateRadiochemistrySphingosineFluorineChemistrySphingosine-1-phosphate receptorPet imagingPhosphateReceptorNuclear chemistryNuclear medicinePositron emission tomographyMedicineBiochemistryOrganic chemistrySphingolipid Metabolism and SignalingCancer, Hypoxia, and MetabolismLipid Membrane Structure and Behavior