Proteome-wide Changes in the mdx-4cv Spleen due to Pathophysiological Cross Talk with Dystrophin-Deficient Skeletal Muscle
Paul Dowling, Stephen Gargan, Margit Zweyer, Michael Henry, Paula Meleady, Dieter Swandulla, Kay Ohlendieck
Abstract
spleen showed significant proteome-wide changes in other protein species that are involved in metabolism, signaling, and cellular architecture. Since the spleen plays a key role in the immune response, these proteomic alterations may reflect pathophysiological cross talk between the lymphoid system and dystrophic muscles, which are affected by both fiber degeneration and inflammation.
Topics & Concepts
Dystrophinmdx mouseDuchenne muscular dystrophySpleenProteomeBiologyMuscular dystrophyITGA7Skeletal muscleInflammationCell biologyProteomicsImmunologyPathologyAnatomyMedicineBioinformaticsBiochemistryGeneticsGeneMuscle Physiology and DisordersAdipose Tissue and MetabolismExercise and Physiological Responses