Transcriptomic-based clustering of human atherosclerotic plaques identifies subgroups with different underlying biology and clinical presentation
Michal Mokrý, Arjan Boltjes, Lotte Slenders, Gemma Bel-Bordes, Kai Cui, Eli Brouwer, Joost M. Mekke, Marie A.C. Depuydt, Nathalie Timmerman, Farahnaz Waissi, Maarten C. Verwer, Adam W. Turner, Mohammad Daud Khan, Chani J. Hodonsky, Ernest Diez Benavente, Robin Hartman, Noortje A. M. van den Dungen, Nico Lansu, E. Nagyova, Koen H.M. Prange, Jason C. Kovacic, Johan Björkegren, Eleftherios Pavlos, Evangelos Andreakos, Heribert Schunkert, Gary K. Owens, Claudia Monaco, Aloke V. Finn, Renu Virmani, Nicholas J. Leeper, Menno P.J. de Winther, Johan Kuiper, Gert J. de Borst, Erik S.G. Stroes, Mete Civelek, Dominique P.V. de Kleijn, Hester M. den Ruijter, Folkert W. Asselbergs, Sander W. van der Laan, Clint L. Miller, Gerard Pasterkamp
Topics & Concepts
TranscriptomePhenotypePathologyComputational biologyBiologyVulnerable plaqueMedicineGeneGene expressionGeneticsAtherosclerosis and Cardiovascular DiseasesSingle-cell and spatial transcriptomicsAdipokines, Inflammation, and Metabolic Diseases