SEOM-GEMCAD-TTD clinical guidelines for localized rectal cancer (2021)
Jaume Capdevila, Ma Auxiliadora Gómez, M. Guillot, David Páez, Carles Pericay, María José Safont, Noelia Tarazona, Ruth Vera, Joana Vidal, Javier Sastre
Abstract
The management of localized rectal cancer requires a multidisciplinary approach to optimize outcomes, reduce morbidity and prevent under or overtreatments. While early stages may obtain benefit of local resections without any additional therapies, locally advanced rectal cancer becomes a challenge defining the better sequential strategy of surgery, radiotherapy and chemotherapy. The latest results of international phase III studies have positioned the total neoadjuvant therapy as a potential new standard of care in high risk rectal cancers, however, the best schedule is still not well defined.