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Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer

Wei Wei, Zhanzhan Feng, Zhihao Liu, Xinyue Li, Hualong He, Kai Ran, Yao Shi, Yongxia Zhu, Tinghong Ye, Chao Gao, Ningyu Wang, Luoting Yu

2021European Journal of Medicinal Chemistry22 citationsDOIOpen Access PDF

Topics & Concepts

ChemistryFocal adhesionIn vivoCancer researchSignal transductionIn vitroIntracellularOvarian cancerKinasePhosphorylationPharmacologyCell biologyCancerBiochemistryInternal medicineBiologyMedicineBiotechnologyCell Adhesion Molecules ResearchProtease and Inhibitor MechanismsUbiquitin and proteasome pathways
Design, synthesis and biological evaluation of 7-((7H-pyrrolo[2,3-d]pyrimidin-4-yl)oxy)-2,3-dihydro-1H-inden-1-one derivatives as potent FAK inhibitors for the treatment of ovarian cancer | Litcius