High plasma C5a and C5b-9 levels during quiescent phases are associated to severe antiphospholipid syndrome subsets
Amelia Ruffatti, Marta Tonello, Antonia Calligaro, Teresa Del Ross, Maria Favarò, Margherita Zen, Antonio Carletto, Virginia Lotti, Eugenia Bertoldo, Francesco Saverio Tedesco, Ariela Hoxha, Domenico Biasi
Abstract
High plasma C5a and C5b-9 levels are considered a clear sign of complement activation. We aimed to evaluate the clinical significance of these two complement activation products during quiescent phases of thrombotic antiphospholipid syndrome (APS) by comparing their plasma levels in the different clinical subsets and relating them to the clinical characteristics and antiphospholipid antibody profile of the patients.
Topics & Concepts
MedicineAntiphospholipid syndromeThrombosisCatastrophic antiphospholipid syndromeInternal medicineGastroenterologyComplement systemAntibodyRefractory (planetary science)ImmunologyPhysicsAstrobiologyBlood Coagulation and Thrombosis MechanismsPeripheral Neuropathies and DisordersComplement system in diseases