Advanced Therapeutic Approach Based on LDHs–Mimetic Oxidoreductase
Kai Song, Wei Yu, Peng Jia, Shan He, Qian Wang, Manman Xu, Hongzhi Liu, Pengtao Bao, Shanyue Guan, Xiaozhong Qu
Abstract
Redox dysregulation is recognized as a key driver in the pathophysiology of numerous refractory diseases, contributing significantly to the progression and poor prognosis. The precise targeting and sophisticated modulation of redox processes within pathological microenvironments thus offer a promising avenue for innovative therapeutic strategies. Layered double hydroxides (LDHs)-based nanozyme lies in the programmable multi-active site architecture, which enables unprecedented functional integration for precise pathological microenvironment remodeling. In this review, the redox modulating mechanisms of LDHs-based nanozyme in these critical disease contexts are systematically explored, with special emphasis on intrinsic enzyme-like activities and structure-activity relationships. At the same time, it highlights how designing LDHs-based nanozyme can manipulate redox homeostasis to precisely reprogram the pathological microenvironment for stimulating effective, context-dependent pro- and anti-inflammatory therapeutic outcomes, which is a crucial requirement in conditions such as tumors and tissue injury. Finally, building upon recent advances, a forward-looking perspective is provided on the current challenges and future research directions in this rapidly progressing field.