Systematic profiling of conditional pathway activation identifies context-dependent synthetic lethalities
Liang Chang, Nancy Yoobin Jung, Adel Atari, Diego J. Rodriguez, Devishi Kesar, Tianyu Song, Matthew G. Rees, Melissa M. Ronan, Ruitong Li, Paloma Ruiz, Saireudee Chaturantabut, Takahiro Ito, Laurens M. van Tienen, Yuen‐Yi Tseng, Jennifer A. Roth, William R. Sellers
Topics & Concepts
BiologyWnt signaling pathwayPI3K/AKT/mTOR pathwayMAPK/ERK pathwayCancer researchComputational biologyContext (archaeology)Gene knockdownGenetic screenSignal transductionCancerGeneticsPhenotypeGenePaleontologyBioinformatics and Genomic NetworksMelanoma and MAPK Pathways14-3-3 protein interactions