Purine nucleoside phosphorylase controls nicotinamide riboside metabolism in mammalian cells
Andrey Kropotov, Veronika Kulikova, Ljudmila Solovjeva, Alexander Yakimov, Kirill Nerinovski, Maria Svetlova, Julia Sudnitsyna, Alena Plusnina, M. D. Antipova, Mikhail Khodorkovskiy, Marie E. Migaud, Stepan Gambaryan, Mathias Ziegler, Andrey Nikiforov
Abstract
synthesis from NR in vivo, in particular, in the kidney. Thus, we establish PNP as a major regulator of NR metabolism in mammals and provide evidence that the health benefits of NR supplementation could be greatly enhanced by concomitant downregulation of PNP activity.
Topics & Concepts
Purine nucleoside phosphorylaseBiochemistryMetabolismRibosideNucleosideNicotinamideChemistryPurine metabolismPurineGlycogen phosphorylaseNAD+ kinaseRiboseBiologyGlycogenEnzymeCalcium signaling and nucleotide metabolismBiochemical and Molecular ResearchAdenosine and Purinergic Signaling