Host Poly(A) Polymerases PAPD5 and PAPD7 Provide Two Layers of Protection That Ensure the Integrity and Stability of Hepatitis B Virus RNA
Fei Liu, Amy C. H. Lee, Fang Guo, Andrew S. Kondratowicz, Holly M. Micolochick Steuer, Angela Miller, Lauren D. Bailey, Xiaohe Wang, Shuai Chen, Steven G. Kultgen, Andrea Cuconati, Andrew G. Cole, Dimitar Gotchev, Bruce D. Dorsey, René Rijnbrand, Angela M. Lam, Michael J. Sofia, Min Gao
Abstract
Chronic hepatitis B affects more than 250 million patients and is a major public health concern worldwide. HBsAg plays a central role in maintaining HBV persistence, and as such, therapies that aim at reducing HBsAg through destabilizing or degrading HBV RNA have been extensively investigated.
Topics & Concepts
BiologyRNAHBsAgHepatitis B virusViral replicationPolymeraseVirologyVirusHepatitis BMolecular biologyDNACell biologyGeneticsGeneHepatitis B Virus StudiesHepatitis Viruses Studies and EpidemiologyHepatitis C virus research