Colonic mucosal microbiota is associated with bowel habit subtype and abdominal pain in patients with irritable bowel syndrome
Charlene Choo, Swapna Mahurkar‐Joshi, Tien S. Dong, Adrienne Lenhart, Venu Lagishetty, Jonathan P. Jacobs, Jennifer S. Labus, Nancee Jaffe, Emeran A. Mayer, Lin Chang
2022American Journal of Physiology-Gastrointestinal and Liver Physiology26 citationsDOIOpen Access PDF
Abstract
Gut mucosal microbiota differs significantly from fecal microbiota in irritable bowel syndrome (IBS) and may play a different role in its pathophysiology. Investigation of colonic mucosal microbiota in the largest cohort of patients with IBS and healthy controls accounting for confounding variables, including diet demonstrated significant differences in mucosal microbiota between IBS bowel habit subtypes but not between IBS and healthy controls. In addition, the study reported gut microbiota is associated with abdominal pain in patients with IBS.
Topics & Concepts
Irritable bowel syndromeGastroenterologyAbdominal painMedicineInternal medicineGastrointestinal motility and disordersGut microbiota and healthDiet and metabolism studies