Differential responses of neurons, astrocytes, and microglia to G-quadruplex stabilization
Natalie Tabor, Conelius Ngwa, Jérémie Mitteaux, Matthew D. Meyer, Jose F. Moruno-Manchon, Liang Zhu, Fudong Liu, David Monchaud, Louise D. McCullough, Andrey S. Tsvetkov
Abstract
in astrocytes and microglia, indicating differences in DNA damage and repair pathways between brain cell types. Taken together, our findings suggest that stabilized G4-DNA contribute to genomic instability in the brain and may represent a novel senescence pathway in brain aging.
Topics & Concepts
MicrogliaGenome instabilityDownregulation and upregulationChromatinCell biologyDNABiologyDNA damageDNA repairDNA methylationGeneGene expressionGeneticsImmunologyInflammationDNA and Nucleic Acid ChemistryAdvanced biosensing and bioanalysis techniquesGenomics and Chromatin Dynamics