Recent Advancements in Typical Friedel–Crafts Alkylation Reactions Focused on Targeting Arene Nucleophiles
Chinmoy Kumar Hazra, Sanjay Singh
Abstract
Abstract This review delves into recent advances and significant breakthroughs in the field of the catalytic Friedel–Crafts alkylation of targeted arenes or heteroarenes. Though a few earlier literatures are referenced, the main emphasis of this review focuses on the literature mainly published between 2015 and March 2023. 1 Introduction 2 History and Background 3 Alcohols as Alkylating Agents 4 Aldehydes and Ketones as Alkylating Agents 5 Alkyl Fluorides as Alkylating Agents 6 Epoxides as Alkylating Agents 7 Cyclopropanes as Alkylating Agents 8 Conclusion and Outlook
Topics & Concepts
ChemistryAlkylationFriedel–Crafts reactionNucleophileAlkylOrganic chemistryCatalysisCombinatorial chemistryCyclopropane Reaction MechanismsAsymmetric Synthesis and CatalysisChemical Synthesis and Reactions