Gene therapy knockdown of Hippo signaling induces cardiomyocyte renewal in pigs after myocardial infarction
Shijie Liu, Ke Li, Leonardo Wagner Florencio, Li Tang, Todd R. Heallen, John P. Leach, Yidan Wang, Francisco Grisanti, James T. Willerson, Emerson C. Perin, Sui Zhang, James F. Martin
Abstract
-shRNA gene therapy to border zone cardiomyocytes in pig hearts after myocardial infarction resulted in tissue renewal and improved function and may have utility in treating heart failure.
Topics & Concepts
Gene knockdownMyocardial infarctionHippo signaling pathwayGenetic enhancementCell biologyCardiologyInfarctionMedicineCancer researchRegeneration (biology)Signal transductionBiologyInternal medicineGeneGeneticsHippo pathway signaling and YAP/TAZCongenital heart defects researchWnt/β-catenin signaling in development and cancer