Stress Response in Entamoeba histolytica Is Associated with Robust Processing of tRNA to tRNA Halves
Manu Sharma, Hanbang Zhang, Gretchen Ehrenkaufer, Upinder Singh
Abstract
In the present study, we report for the first time the presence of tRNA-derived fragments in Entamoeba . tRNA-derived fragments were identified by bioinformatics analyses of small-RNA sequencing data sets from the parasites and also confirmed experimentally. We found that tRNA halves accumulated in parasites exposed to environmental stress or during the developmental process of encystation.
Topics & Concepts
Transfer RNAEntamoeba histolyticaRNABiologyEntamoebaGeneticsGeneAmoebic Infections and TreatmentsRNA modifications and cancerParasitic Infections and Diagnostics