High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization
Shu Feng, Chongyun Wu, Peibin Zou, Qianting Deng, Zhe Chen, Meng Li, Ling Zhu, Fanghui Li, Timon Cheng‐Yi Liu, Rui Duan, Luodan Yang
Abstract
Our findings indicate that HIIT ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype and astrocyte phenotype-associated AQP4 polarization. These changes promote Aβ and p-tau clearance from the brain tissue through the glymphatic system and the kidney.
Topics & Concepts
NeurodegenerationAstrocyteNeuroscienceNeuNNeuroprotectionAstrogliosisMedicinePathologyBiologyDiseaseCentral nervous systemImmunohistochemistryIon Transport and Channel RegulationCerebrospinal fluid and hydrocephalusAlzheimer's disease research and treatments