Cyclodextrins as Anti-inflammatory Agents: Basis, Drugs and Perspectives
Silvia Lucia Appleton, Silvia Navarro‐Orcajada, Francisco J. Martínez‐Navarro, Fabrizio Caldera, Manuel López-Nicolás, Francesco Trotta, Adrián Matencio
Abstract
Inflammation is a biological response of the immune system to harmful stimuli. Importantly, inflammation is also a hallmark of several human diseases such as cancer or diabetes. Novel drugs to treat this response are constantly researched, but the formulation is usually forgotten. Cyclodextrins (CDs) are a well-known excipient for complexing and drug delivery. Anti-inflammatory drugs and bioactive compounds with similar activities have been favored from these CD processes. CDs also illustrate anti-inflammatory activity per se. This review tried to describe the capacities of CDs in this field, and is divided into two parts: Firstly, a short description of the inflammation disease (causes, symptoms, treatment) is explained; secondly, the effects of different CDs alone or forming inclusion complexes with drugs or bioactive compounds are discussed.