Porphyromonas gingivalis Outer Membrane Vesicles Promote Apoptosis via msRNA-Regulated DNA Methylation in Periodontitis
Ruyi Fan, Yi Zhou, Xu Chen, Xianmei Zhong, Fanzhen He, Wenzao Peng, Lu Li, Xiaoqian Wang, Yan Xu
Abstract
P. gingivalis is a bacterium often associated with periodontitis. This study demonstrates that (i) sRNA45033 in P. gingivalis OMVs targets CBX5, (ii) CBX5 regulates the methylation of p53 DNA and its expression, which is associated with apoptosis, and (iii) a novel mechanism of interaction between hosts and pathogens is mediated by OMVs in the occurrence of periodontitis.
Topics & Concepts
Porphyromonas gingivalisApoptosisPeriodontitisChemistryIn vivoDNA methylationMicrobiologyBacterial outer membraneCell biologyBiologyGene expressionGeneMedicineBiochemistryDentistryEscherichia coliBiotechnologyOral microbiology and periodontitis researchBacterial Infections and VaccinesImmune Response and Inflammation