Lactoferrin-Hexon Interactions Mediate CAR-Independent Adenovirus Infection of Human Respiratory Cells
B. David Persson, Annasara Lenman, Lars Frängsmyr, Markus Schmid, Clas Ahlm, Andreas Plückthun, Håvard Jenssen, Niklas Arnberg
Abstract
Many viruses enter target cells using cell adhesion molecules as receptors. Paradoxically, these molecules are abundant on the lateral and basolateral side of intact, polarized, epithelial target cells, but absent on the apical side that must be penetrated by incoming viruses to initiate infection. Our study provides a model whereby viruses use different mechanisms to infect polarized epithelial cells depending on which side of the cell-apical or lateral/basolateral-is attacked. This study may also be useful to understand the biology of other viruses that use cell adhesion molecules as receptors.
Topics & Concepts
BiologyLactoferrinCell biologyReceptorCell adhesion moleculeViral entryVirologyVirusInnate immune systemViral replicationGeneticsVirus-based gene therapy researchViral gastroenteritis research and epidemiologyRespiratory viral infections research