MnGA with multiple enzyme-like properties for acute wound healing by reducing oxidative stress and modulating signaling pathways
Xueting Guo, Wenqi Wang, Liting Lin, Jie Shan, Junyao Zhu, Shipeng Ning, Hanmei Li, Xianwen Wang, Decheng Lü
Abstract
via CAT-like activity, resulting in a cascade of catalytic reactions to scavenge reactive oxygen species (ROS). Moreover, the scavenging of RNS by MnGA can amplify the anti-inflammatory effect in combination with the scavenging of ROS. RNA sequencing of mouse skin tissue further revealed that MnGA significantly reduces inflammation by modulating the nuclear factor kappa-B (NF-κB), Toll-like receptor (TLR), and NOD-like receptor (NLR) signaling pathways and promotes skin regeneration. In summary, MnGA nanocatalysts possess excellent antioxidative and anti-inflammatory properties, highlighting their potential applications in wound healing and inflammation treatment.