Spatiotemporal dynamics of inner ear sensory and non-sensory cells revealed by single-cell transcriptomics
Taha A. Jan, Yasmin Eltawil, Angela H. Ling, Leon Chen, Daniel C. Ellwanger, Stefan Heller, Alan G. Cheng
Abstract
transitional epithelial cells exhibit a dynamic and proliferative phase to generate new supporting cells, followed by coordinated differentiation into hair cells. Taken together, our study reveals a sequential and coordinated process by which non-sensory epithelial cells contribute to growth of the postnatal mouse sensory epithelium.
Topics & Concepts
Sensory systemInner earTranscriptomeDynamics (music)BiologyNeuroscienceCellGeneticsGeneGene expressionPsychologyPedagogyHearing, Cochlea, Tinnitus, GeneticsSingle-cell and spatial transcriptomicsCancer-related molecular mechanisms research