Synthesis of 2-trifluoromethylquinolines through rhodium-catalysed redox-neutral [3 + 3] annulation between anilines and CF<sub>3</sub>-ynones using traceless directing groups
Haichao Huang, Hailong Wang, Chao Gong, Zhenjing Zhuang, Wenmin Feng, Si‐Hai Wu, Lianhui Wang
Abstract
Rhodium-catalysed [3 + 3]-cycloaddition of acetanilides with CF 3 -ynones was achieved through a traceless directing-group strategy, which delivered 2-trifluromethylquinolines exhibiting favorable blue emissions.
Topics & Concepts
ChemistryRhodiumAnnulationCycloadditionAcetanilideMedicinal chemistryRedoxCombinatorial chemistryCatalysisOrganic chemistryFluorine in Organic ChemistryCatalytic C–H Functionalization MethodsCyclopropane Reaction Mechanisms