Application of the Tissue-Engineered Plant Scaffold as a Vascular Patch
Hualong Bai, Boao Xie, Zhiwei Wang, Ming‐Xing Li, Peng Sun, Shunbo Wei, Wang Wang, Haoliang Wu, Lei Bai, Jingan Li
Abstract
-glycolic acid (PLGA)-based rapamycin nanoparticles (nanoparticles). Nanoparticle-perfused leaves showed decreased neointimal thickness after implantation on day 14; there were also fewer CD68-positive cells and PCNA-positive cells in the neointima in the nanoparticle-perfused patches than in the control patches. Onion cellulose was decellularized, coated with rapamycin nanoparticles, and implanted in the rat; the nanoparticle-coated onion cellulose patches also showed decreased neointimal thickness. These data show that natural plant-based scaffolds may be used as novel scaffolds for tissue-engineered vascular patches. However, further modifications are needed to enhance patch strength for artery implantations.