Electrochemically Enabled Dehydrogenative Phosphorothiolation of 2<i>H</i>‐Indazoles under Electrolyte‐Free Conditions
Payel Ghosh, Alakananda Hajra
Abstract
Abstract We have developed an electrochemical method for phosphorothiolation of 2 H ‐indazoles using S ‐hydrogen phosphorothioates via cross dehydrogenative coupling reaction under metal‐free and electrolyte‐free conditions. This protocol is compatible with electron donating groups like −Me, −OMe, halogen and elctron withdrawing groups such as −COOEt, affording respective indazolyl phosphorothioates in 62%‐91% yields. Comprehensive mechanistic studies indicate that the reaction proceeds through a radical pathway. magnified image
Topics & Concepts
ChemistryElectrolyteElectrochemistryHalogenCombinatorial chemistryOrganic chemistryElectrodePhysical chemistryAlkylSulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods