<i>Helicobacter pylori</i> antibiotic eradication coupled with a chemically defined diet in INS-GAS mice triggers dysbiosis and vitamin K deficiency resulting in gastric hemorrhage
Lisa Quinn, Alexander Sheh, Jessie L Ellis, Donald E. Smith, Sarah L. Booth, Xueyan Fu, Sureshkumar Muthupalani, Zhongming Ge, Dylan Puglisi, Timothy C. Wang, Tamas A. Gonda, Hilda Holcombe, James G. Fox
Abstract
were confirmed in antibiotic-treated mice. The fecal menaquinone profile of antibiotic-treated mice had reduced MK5 and MK6 and increased MK7 and MK11 compared to antibiotic-free mice. Loss of menaquinone-producing microbes due to antibiotics altered the enteric production of vitamin K. This study highlights the role of diet and the microbiome in maintaining vitamin K homeostasis.
Topics & Concepts
DysbiosisAntibioticsBiologyInternal medicineGut floraGastroenterologyImmunologyMicrobiologyMedicineHelicobacter pylori-related gastroenterology studiesVitamin K Research StudiesIntestinal and Peritoneal Adhesions