The role of GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals in Th17 responses counteracted by PPARγ agonists
Yumeng Miao, Yun Zheng, Yanzhi Geng, Ling Yang, Na Cao, Yue Dai, Zhifeng Wei
Abstract
PPARγ agonists repressed Th17 responses by counteracting GLS1-mediated glutaminolysis/2-HG/H3K4me3 and GSH/ROS signals, which is beneficial for Th17 cell-related immune dysregulation.
Topics & Concepts
GlutaminolysisChemistryCell biologyH3K4me3Peroxisome proliferator-activated receptorReactive oxygen speciesCancer researchBiochemistryBiologyMetabolismReceptorGlycolysisPromoterGene expressionGeneCancer, Hypoxia, and MetabolismAdenosine and Purinergic SignalingAmino Acid Enzymes and Metabolism