Design, synthesis, and anti-cancer evaluation of new pyrido[2,3-d]pyrimidin-4(3H)-one derivatives as potential EGFRWT and EGFRT790M inhibitors and apoptosis inducers
Heba S. A. Elzahabi, Eman S. Nossier, Rania A. Alasfoury, May A. El‐Manawaty, Sara M. Sayed, Eslam B. Elkaeed, Ahmed M. Metwaly, Mohamed Hagras, Ibrahim H. Eissa
Abstract
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Topics & Concepts
ChemistryStereochemistryDocking (animal)IC50ApoptosisCytotoxicityInhibitory postsynaptic potentialLead compoundCytotoxic T cellStructure–activity relationshipCell cultureCombinatorial chemistryIn vitroPharmacologyBiochemistryBiologyMedicineGeneticsNursingNeuroscienceCancer therapeutics and mechanismsQuinazolinone synthesis and applicationsLung Cancer Treatments and Mutations