Novel carbazolyl–thiazolyl–chromone and carbazolyl–thiazolyl–pyrazole hybrids: synthesis, cytotoxicity evaluation and molecular docking studies
Noha M. Hassanin, Tarik E. Ali, Mohammed A. Assiri, Somaia M. Abdel‐Kariem
Abstract
anticancer activities against HCT116, PC3 and HepG2 cancer cell lines using the standard SRB method. Fortunately, both compounds 5dand5e were the most active against all cancer cell lines compared with doxorubicin and can be promising anticancer agents. Both bioactive products 5band5e were studied by the molecular docking to see how they bind with VEGFR-2 receptor. The results indicated that those compounds exhibited high affinities towards VEGFR-2 and established remarkably similar interactions to those of the powerful VEGFR-2-KDR.
Topics & Concepts
ChromoneCarbazolePyrazoleChemistryHybridCombinatorial chemistryStereochemistryOrganic chemistryBiologyBotanySynthesis and biological activitySynthesis of Organic CompoundsMulticomponent Synthesis of Heterocycles