Inhibition of the INa/K and the activation of peak INa contribute to the arrhythmogenic effects of aconitine and mesaconitine in guinea pigs
Xiangchong Wang, Qingzhong Jia, Yulou Yu, Handong Wang, Huicai Guo, Xindi Ma, Chuntong Liu, Xueyan Chen, Qingfeng Miao, Bingcai Guan, Suwen Su, Heming Wei, Chuan Wang
Topics & Concepts
AconitineVentricular fibrillationPharmacologyInternal medicineCardiotoxicityVentricular tachycardiaSodium channelMedicineTetrodotoxinChemistryPatch clampSodiumElectrophysiologyToxicityOrganic chemistryPlant-based Medicinal ResearchCardiac electrophysiology and arrhythmiasPoisoning and overdose treatments